COVID-19, Influenza, and RSV Wastewater Monitoring in the U.S. | Week of November 15, 2025

Summary: Week of 11/15/25

Biobot’s national wastewater network shows that RSV continues to pick up, especially in the South and Northeast, through November 15 (week 46). We’re also seeing influenza and SARS-CoV-2 start to increase, though slowly. We anticipate both will accelerate soon as we head into holiday travel.

Due to the government shutdown, the CDC is lagging in updating their dashboards, so we don’t know the current hospitalization rates for any of the respiratory viruses. They haven’t been updated since September 27th.

The Bottom Line: Heading into Thanksgiving travel, we’re actually in pretty good shape with a slower start to this year’s respiratory season. But, things will only pick up from here around the holidays. RSV and flu are top of mind right now, as they are showing the greatest increases in wastewater. It’s still a perfect time to get vaccinated, and consider reducing contact if you’re feeling ill.

National Outlook

COVID-19

National SARS-CoV-2 concentrations are slightly increasing.

Influenza

National influenza A & B concentrations are slightly increasing.

RSV

National RSV concentrations are increasing.

Regional

The South

COVID-19: SARS-CoV-2 concentrations are holding steady in the South.

Influenza: Influenza A and B concentrations are slightly increasing in the South.

RSV: RSV concentrations are increasing in the South.

The Midwest

COVID-19: SARS-CoV-2 concentrations are increasing in the Midwest.

Influenza: Influenza A concentrations are holding steady in the Midwest, while influenza B concentrations are slightly increasing.

RSV: RSV concentrations are holding steady at very low levels in the Midwest.

The Northeast

COVID-19: SARS-CoV-2 concentrations are increasing in the Northeast.

Influenza: Influenza A and B concentrations are holding steady at very low levels in the Northeast.

RSV: RSV concentrations are increasing in the Northeast.

The West

COVID-19: SARS-CoV-2 concentrations are increasing in the West.

Influenza: Influenza A concentrations are slightly increasing in the West, while influenza B concentrations are holding steady.

RSV: RSV concentrations are holding steady at very low levels in the West.

Footnotes:

We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — see our blog here and please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1). We will share any important updates as we have them via Bluesky and in the risk reports.

Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through November 15, 2025 (MMWR week 46). Clinical data for RSV, influenza, and COVID-19 from the Centers for Disease Control and Prevention have not been updated since September 27, 2025 (MMWR week 39) due to the government shutdown.