Summary: Week of 4/11/26
Biobot’s national network shows that the three major respiratory viruses—SARS-CoV-2, influenza, and RSV—are all declining across the U.S. But that doesn’t mean the respiratory threat has disappeared. Human metapneumovirus (HMPV), another respiratory pathogen that can make people sick, is still climbing. We’ve been watching it for months, and the latest data show it hasn’t hit its seasonal peak. It’s a good reminder that the respiratory season doesn’t always end when the headline viruses start to fall.
The Bottom Line: While the major respiratory viruses are declining, the virus season is not over. Flu B, RSV, and HMPV are all circulating at high levels and for people at higher risk of severe illness—older adults, young children, and those who are pregnant or with underlying health conditions—it’s still a good time to consider added protections, especially in crowded indoor settings or before seeing vulnerable family members.
National Outlook
COVID-19
Nationally, SARS-CoV-2 is decreasing.
Influenza
Nationally, influenza A and B are decreasing.
RSV
Nationally, RSV is decreasing.
HMPV
Nationally, HMPV is increasing.
Regional Outlook
The South
COVID-19: SARS-CoV-2 is decreasing in the South.
Influenza: Influenza A and B are decreasing in the South.
RSV: RSV is slightly increasing in the South.
HMPV: HMPV is increasing in the South.
The Midwest
COVID-19: SARS-CoV-2 is decreasing in the Midwest.
Influenza: Influenza A and B are decreasing in the Midwest.
RSV: RSV is decreasing in the Midwest.
HMPV: HMPV is increasing in the Midwest.
The Northeast
COVID-19: SARS-CoV-2 is decreasing in the Northeast.
Influenza: Influenza A and B are decreasing in the Northeast.
RSV: RSV is increasing in the Northeast.
HMPV: HMPV is increasing in the Northeast.
The West
COVID-19: SARS-CoV-2 is decreasing in the West.
Influenza: Influenza A and B are decreasing in the West.
RSV: RSV is decreasing in the West.
HMPV: HMPV is decreasing in the West.
Footnotes:
We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1). We will share any important updates as we have them. Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through April 4, 2026 (MMWR week 13).