Summary: Week of 4/25/26
Respiratory viruses are continuing to move in the right direction. Across Biobot’s national wastewater network, every major virus we track is declining nationally and in every region, including SARS-CoV-2, influenza A and B, RSV, and HMPV.
That is great news. But we’re not all the way back to low-season levels yet. A few viruses are still hanging on and remain slightly elevated including flu B, RSV, and especially HMPV.
The Bottom Line: Overall respiratory risk is coming down, which is great. But, there’s still some viral activity worth paying attention to. RSV, flu B, and HMPV are still circulating higher than others, and can cause illness, especially in young children, older adults, immunocompromised people, and others at higher risk. The usual precautions still matter around higher-risk loved ones: stay home when sick, consider masking in crowded indoor spaces if you have symptoms or recent exposure, and keep up with vaccines when recommended.
National Outlook
COVID-19
Nationally, SARS-CoV-2 is decreasing.
Influenza
Nationally, influenza A and B are decreasing.
RSV
Nationally, RSV is decreasing.
HMPV
Nationally, HMPV is decreasing.
Regional Outlook
The South
COVID-19: SARS-CoV-2 is decreasing in the South.
Influenza: Influenza A and B are decreasing in the South.
RSV: RSV is decreasing in the South.
HMPV: HMPV is decreasing in the South.
The Midwest
COVID-19: SARS-CoV-2 is decreasing in the Midwest.
Influenza: Influenza A and B are decreasing in the Midwest.
RSV: RSV is decreasing in the Midwest.
HMPV: HMPV is decreasing in the Midwest.
The Northeast
COVID-19: SARS-CoV-2 is decreasing in the Northeast.
Influenza: Influenza A and B are decreasing in the Northeast.
RSV: RSV is decreasing in the Northeast.
HMPV: HMPV is decreasing in the Northeast.
The West
COVID-19: SARS-CoV-2 is decreasing in the West.
Influenza: Influenza A and B are decreasing in the West.
RSV: RSV is decreasing in the West.
HMPV: HMPV is holding steady in the West.
Footnotes:
We continue to monitor evolving health threats, like measles outbreaks and H5N1 avian influenza, and can test samples specifically for these viruses. Please reach out to hello@biobot.io if interested. We will share any important updates as we have them. Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through April 25, 2026 (MMWR week 16).