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Respiratory Virus Risk Reports

Comprehensive Insights for COVID-19, Influenza, and RSV

COVID-19, Influenza, and RSV Wastewater Monitoring in the U.S. | Week of April 5, 2025

 

Throughout the respiratory season, we analyze wastewater for the presence of respiratory syncytial virus (RSV) and influenza virus (types A and B). Together with COVID-19, these three pathogens are outsized contributors to our seasonal respiratory illness burden. In this data series, we’ll guide you through the wealth of data we’ve gathered from our Biobot Network of national sampling sites, aiming to shed light on emerging trends in respiratory virus activity and community viral load. Our goal is to equip you with information to make informed decisions.

Data Note: Samples are collected from participating locations, and processed by our lab team on a rolling basis. Each point on the figure represents the weekly average concentration, from Sunday – Saturday (corresponding to the MMWR week), aligned to that week’s Saturday.

Contributors
Marisa Donnelly, PhD

Public Health Partnerships Epidemiologist

Previous Risk Reports

Summary: Week of 4/5/25

Biobot’s national wastewater network shows that COVID-19, influenza A & B, and RSV are decreasing in week 14 (through April 5, 2025). National hospitalizations for influenza remain the highest compared to the other respiratory viruses but continue to decrease, currently at 1.4 per 100,000 people in week 13 (through March 29, 2025). National hospitalizations for COVID-19 and RSV also decreased in week 13, currently at 1.1 and 0.1 per 100,000 people, respectively.

The Bottom Line: We are getting closer to the end of the respiratory season but flu activity remains elevated — we can expect a couple of more weeks of transmission. It’s good to remember these recommendations to stay healthy: stay current with vaccinations, consider wearing a mask in crowded areas, and if you feel unwell, minimize contact with others.

National Outlook

COVID-19

National SARS-CoV-2 concentrations are decreasing.

Influenza

National influenza A and B concentrations are decreasing.

RSV

National RSV concentrations are decreasing.

Regional

The South

COVID-19: SARS-CoV-2 concentrations are decreasing in the South.

Influenza: Influenza A and B concentrations are decreasing in the South.

RSV: RSV concentrations are decreasing in the South.

The Midwest

COVID-19: SARS-CoV-2 concentrations are decreasing in the Midwest.

Influenza: Influenza A concentrations are decreasing in the Midwest, while influenza B is holding steady.   

RSV: RSV concentrations are decreasing in the Midwest.

The Northeast

COVID-19: SARS-CoV-2 concentrations are decreasing in the Northeast.

Influenza: Influenza A and B concentrations are decreasing in the Northeast.

RSV: RSV concentrations are decreasing in the Northeast.

The West

COVID-19: SARS-CoV-2 concentrations are holding steady in the West.

Influenza: Influenza A and B concentrations are decreasing in the West.

RSV: RSV concentrations are decreasing in the West.

Footnotes: 
We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1).  We will share any important updates as we have them via Bluesky and in the risk reports.

Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through April 5, 2025 (MMWR week 14). Clinical data for RSV, influenza, and COVID-19 are from the Centers for Disease Control and Prevention. Updates to clinical data are through March 29, 2025 (MMWR week 13).