COVID-19, Influenza, and RSV Wastewater Monitoring in the U.S. | Week of December 6, 2025

Summary: Week of 12/06/25

Biobot’s national wastewater network shows that the three major respiratory viruses—COVID-19, influenza, and RSV—continue to increase through December 6 (week 49). CDC’s clinical data show that hospitalizations for flu and RSV are increasing. COVID-19 hospitalizations have not yet increased, though with recent upticks in wastewater, we expect to see an increase in hospitalizations soon.

The Bottom Line: Respiratory viruses are picking up across the board. Now is the time to think about the steps you and your family can take to stay healthy this winter.

National Outlook

COVID-19

National SARS-CoV-2 concentrations are increasing.

Influenza

National influenza A & B concentrations are increasing.

RSV

National RSV concentrations are increasing.

Regional

The South

COVID-19: SARS-CoV-2 concentrations are increasing in the South.

Influenza: Influenza A and B concentrations are increasing in the South.

RSV: RSV concentrations are increasing in the South.

The Midwest

COVID-19: SARS-CoV-2 concentrations are increasing in the Midwest.

Influenza: Influenza A and B concentrations are increasing in the Midwest.

RSV: RSV concentrations are increasing in the Midwest.

The Northeast

COVID-19: SARS-CoV-2 concentrations are increasing in the Northeast.

Influenza: Influenza A concentrations are increasing in the Northeast while influenza B concentrations are fluctuating.

RSV: RSV concentrations are increasing in the Northeast.

The West

COVID-19: SARS-CoV-2 concentrations are increasing in the West.

Influenza: Influenza A concentrations are increasing in the West, while influenza B concentrations are fluctuating.

RSV: RSV concentrations are increasing in the West.

Footnotes:

We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — see our blog here and please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1). We will share any important updates as we have them via Bluesky and in the risk reports.

Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through December 6, 2025 (MMWR week 49). Clinical data for RSV, influenza, and COVID-19 from the Centers for Disease Control and Prevention are through November 29, 2025 (MMWR week 48).