COVID-19, Influenza, and RSV Wastewater Monitoring in the U.S. | Week of May 24, 2025

Summary: Week of 5/24/25

Biobot’s national wastewater network shows that COVID-19, influenza A & B, and RSV are declining in week 21 (through May 24, 2025). National hospitalizations for COVID-19 and RSV continue to decline, currently at 0.9 and 0.1 per 100,000 people in week 20 (through May 17, 2025). Flu hospitalizations rates have not been updated on the CDC website since May 3rd.

The Bottom Line: All major respiratory viruses are pretty low right now. Enjoy the respite! We’ll continue to keep an eye on things.

National Outlook

COVID-19

National SARS-CoV-2 concentrations are declining.

Influenza

National flu A & B concentrations are declining.

RSV

National RSV concentrations are declining.

Regional

The South

COVID-19: SARS-CoV-2 concentrations are declining in the South.

Influenza: Influenza A & B concentrations in the South are holding steady at very low levels.

RSV: RSV concentrations are declining in the South.

The Midwest

COVID-19: SARS-CoV-2 concentrations are declining in the Midwest.

Influenza: Influenza A & B concentrations are holding steady at very low levels in the Midwest.  

RSV: RSV concentrations are declining in the Midwest.

The Northeast

COVID-19: SARS-CoV-2 concentrations are declining in the Northeast.

Influenza: Influenza A concentrations are holding steady at very-low levels in the Northeast, while influenza B is declining.

RSV: RSV concentrations are declining in the Northeast.

The West

COVID-19: SARS-CoV-2 concentrations are declining in the West.

Influenza: Influenza A & B concentrations in the West are holding steady at very-low and low levels, respectively.

RSV: RSV concentrations are declining in the West.


Footnotes: 
We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — see our blog here and please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1). We will share any important updates as we have them via Bluesky and in the risk reports.

Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through May 24, 2025 (MMWR week 21). Clinical data for RSV, influenza, and COVID-19 are from the Centers for Disease Control and Prevention. Updates to clinical data are through May 17, 2025 (MMWR week 20).

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