COVID-19, Influenza, and RSV Wastewater Monitoring in the U.S. | Week of May 31, 2025

Summary: Week of 5/31/25

Biobot’s national wastewater network shows that COVID-19, influenza A & B, and RSV are holding steady at very low levels in week 22 (through May 31, 2025). National hospitalizations for COVID-19 and RSV continue to decline, currently at 0.8 and 0.1 per 100,000 people in week 21 (through May 24, 2025). Flu hospitalizations rates have not been updated on the CDC website since May 3rd.

The Bottom Line: All major respiratory viruses are pretty low right now. Enjoy the respite! We’ll continue to keep an eye on things.

National Outlook

COVID-19

National SARS-CoV-2 concentrations are holding steady at very low levels.

Influenza

National flu A & B concentrations are holding steady at very low levels.

RSV

National RSV concentrations are holding steady at very low levels.

Regional

The South

COVID-19: SARS-CoV-2 concentrations are holding steady at low levels in the South.

Influenza: Influenza A & B concentrations in the South are holding steady at very low levels.

RSV: RSV concentrations are holding steady at very low levels in the South.

The Midwest

COVID-19: SARS-CoV-2 concentrations are decreasing in the Midwest.

Influenza: Influenza A & B concentrations are holding steady at very low levels in the Midwest. 

RSV: RSV concentrations are holding steady at very low levels in the Midwest

The Northeast

COVID-19: SARS-CoV-2 concentrations are holding steady at low levels in the Northeast.

Influenza: Influenza A & B concentrations are holding steady at very low levels in the Northeast. 

RSV: RSV concentrations are holding steady at very low levels in the Northeast.

The West

COVID-19: SARS-CoV-2 concentrations are holding steady at low levels in the West.

Influenza: Influenza A & B concentrations are holding steady at very low levels in the West.

RSV: RSV concentrations are holding steady at very low levels in the West.


Footnotes: 
We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — see our blog here and please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1). We will share any important updates as we have them via Bluesky and in the risk reports.

Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through May 31, 2025 (MMWR week 22). Clinical data for RSV, influenza, and COVID-19 are from the Centers for Disease Control and Prevention. Updates to clinical data are through May 24, 2025 (MMWR week 21).

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