COVID-19, Influenza, and RSV Wastewater Monitoring in the U.S. | Week of November 29, 2025

Summary: Week of 11/29/25

Biobot’s national wastewater network shows that all three major respiratory viruses—COVID-19, influenza, and RSV—are now increasing through November 29 (week 48). CDC’s clinical data, which is finally back online following the government shutdown, shows that hospitalizations of flu and RSV are picking up, while COVID-19 hospitalizations remain low and stable.

The Bottom Line: Following the Thanksgiving holiday, when many people traveled to visit loved ones across the country, respiratory viruses picked up—COVID-19, flu, and RSV are all increasing.

National Outlook

COVID-19

National SARS-CoV-2 concentrations are increasing.

Influenza

National influenza A & B concentrations are increasing.

RSV

National RSV concentrations are increasing.

Regional

The South

COVID-19: SARS-CoV-2 concentrations are increasing in the South.

Influenza: Influenza A and B concentrations are increasing in the South.

RSV: RSV concentrations are increasing in the South.

The Midwest

COVID-19: SARS-CoV-2 concentrations are increasing in the Midwest.

Influenza: Influenza A and B concentrations are increasing in the Midwest.

RSV: RSV concentrations are increasing in the Midwest.

The Northeast

COVID-19: SARS-CoV-2 concentrations are increasing in the Northeast.

Influenza: Influenza A and B concentrations are increasing in the Northeast.

RSV: RSV concentrations are holding steady in the Northeast.

The West

COVID-19: SARS-CoV-2 concentrations are increasing in the West.

Influenza: Influenza A concentrations are holding steady in the West, while influenza B concentrations are increasing.

RSV: RSV concentrations are holding steady in the West.

Footnotes:

We continue to monitor the evolving H5N1 influenza virus situation, and can now test samples specifically for H5 (including H5N1) — see our blog here and please reach out to hello@biobot.io if interested. A quick reminder that Biobot’s influenza A assay described in this report includes the H5N1 influenza subtype, which is an influenza A virus, but does not distinguish between the different subtypes of influenza A (e.g. H5N1 vs H1N1). We will share any important updates as we have them via Bluesky and in the risk reports.

Wastewater data from Biobot Analytics for RSV, influenza, and SARS-CoV-2 are through November 29, 2025 (MMWR week 48). Clinical data for RSV, influenza, and COVID-19 from the Centers for Disease Control and Prevention are through November 22, 2025 (MMWR week 47).